Introduction:Sitagliptin was developed by Merck & Co. and approved for medical use in the United States in 2006. In 2020, it was the 74th most commonly prescribed medication in the United States, with more than 9 million prescriptions.Sitagliptin, sold under the brand name Januvia among others, is an anti-diabetic medication used to treat type II diabetes. In the United Kingdom it is listed as less preferred than metformin or a sulfonylurea.It is taken by mouth.It is also available in the fixed-dose combination medication sitagliptin metformin (Janumet, Janumet XR).Janumet and Janumet XR drugs are approved to improve blood sugar control in